Mechanism of Adenine Inhibition in Adenine-Sensitive Mutants of Salmonella typhimurium
نویسندگان
چکیده
منابع مشابه
HISTIDINE MUTANTS REQUIRING ADENINE: SELECTION OF MUTANTS WITH REDUCED hisG EXPRESSION IN SALMONELLA TYPHIMURIUM H
A method is described for the selection of Salmonella typhimurium mutants with reduced levels of hisG enzyme activity. This method is based on the fact that the hisG enzyme catalyzes the consumption of ATP in the first step of histidine biosynthesis. Normally, this reaction is closely regulated, both by feedback inhibition and by repression of the operon. However, conditions can be set up that ...
متن کاملHistidine mutants requiring adenine: selection of mutants with reduced hisG expression in Salmonella typhimurium.
A method is described for the selection of Salmonella typhimurium mutants with reduced levels of hisG enzyme activity. This method is based on the fact that the hisG enzyme catalyzes the consumption of ATP in the first step of histidine biosynthesis. Normally, this reaction is closely regulated, both by feedback inhibition and by repression of the operon. However, conditions can be set up that ...
متن کاملMutant of Salmonella typhimurium LT2 deficient in DNA adenine methylation.
A mutant of Salmonella typhimurium LT2 deficient in methylation of the adenine residues in the sequence 5'-GATC-3' was isolated. The mutation (dam-1) was linked to the cysG locus, and the properties of the mutant were similar to those of Escherichia coli dam mutants. Reversion of the hisC3076 frameshift marker by 9-aminoacridine was substantially enhanced by the dam-1 mutation, implying a direc...
متن کاملEnhancement by Adenine of the Inhibition of Salmonella Typhimurium by Ethionine.
Smith, Robert C. (Auburn University, Auburn. Ala.), and W. D. Salmon. Enhancement by adenine of the inhibition of Salmonella typhimurium by ethionine. J. Bacteriol. 89:1494-1498. 1965.-The inhibition by ethionine of the growth of Salmonella typhimurium was increased by adenine and several other purines. This effect was counteracted by the addition of methionine to the cultures. There was no pre...
متن کاملSalmonella DNA adenine methylase mutants confer cross-protective immunity.
Salmonella isolates that lack or overproduce DNA adenine methylase (Dam) elicited a cross-protective immune response to different Salmonella serovars. The protection afforded by the Salmonella enterica serovar Typhimurium Dam vaccine was greater than that elicited in mice that survived a virulent infection. S. enterica serovar Typhimurium Dam mutant strains exhibited enhanced sensitivity to med...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 1966
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.91.2.507-513.1966